Comparison of RNFL thickness and RPE-normalized RNFL attenuation coefficient for glaucoma diagnosis

Koenraad Arndt Vermeer, Josine G van der Schoot, Hans G Lemij, Johannes F de Boer

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Recently, a method to determine the retinal nerve fiber layer (RNFL) attenuation coefficient, based on normalization on the retinal pigment epithelium, was introduced. In contrast to conventional RNFL thickness measures, this novel measure represents a scattering property of the RNFL tissue. In this paper, we compare the RNFL thickness and the RNFL attenuation coefficient on 10 normal and 8 glaucomatous eyes by analyzing the correlation coefficient and the receiver operator curves (ROCs). The thickness and attenuation coefficient showed moderate correlation (r=0.82). Smaller correlation coefficients were found within normal (r=0.55) and glaucomatous (r=0.48) eyes. The full separation between normal and glaucomatous eyes based on the RNFL attenuation coefficient yielded an area under the ROC (AROC) of 1.0. The AROC for the RNFL thickness was 0.9875. No statistically significant difference between the two measures was found by comparing the AROC. RNFL attenuation coefficients may thus replace current RNFL thickness measurements or be combined with it to improve glaucoma diagnosis.
Original languageEnglish
Title of host publicationOphthalmic Technologies XXIII. (eds. Manns F, Söderberg PG, Ho A). Proc. of the SPIE 2013; 8567
Publication statusPublished - 2013


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