Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy

Danial Mohabati; Elon H C van Dijk; Thomas J van Rijssen; Eiko K de Jong; Myrte B Breukink; Jose P Martinez-Ciriano; Greet Dijkman; Carel B Hoyng; Sascha Fauser; Suzanne Yzer; Camiel JF Boon

doi:10.2147/OPTH.S174573

Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy

Danial Mohabati, Elon H C van Dijk, Thomas J van Rijssen, Eiko K de Jong, Myrte B Breukink, Jose P Martinez-Ciriano, Greet Dijkman, Carel B Hoyng, Sascha Fauser, Suzanne Yzer, Camiel JF Boon

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).

Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.

Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple "hot spots" of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit.

Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.

Original language	English
Pages (from-to)	2167-2176
Number of pages	10
Journal	Clinical ophthalmology (Auckland, N.Z.)
Volume	12
DOIs	https://doi.org/10.2147/OPTH.S174573
Publication status	Published - 2018

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10.2147/OPTH.S174573

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Mohabati, D., van Dijk, E. H. C., van Rijssen, T. J., de Jong, E. K., Breukink, M. B., Martinez-Ciriano, J. P., Dijkman, G., Hoyng, C. B., Fauser, S., Yzer, S., & Boon, C. JF. (2018). Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy. Clinical ophthalmology (Auckland, N.Z.), 12, 2167-2176. https://doi.org/10.2147/OPTH.S174573

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abstract = "Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple {"}hot spots{"} of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit.Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.",

author = "Danial Mohabati and {van Dijk}, {Elon H C} and {van Rijssen}, {Thomas J} and {de Jong}, {Eiko K} and Breukink, {Myrte B} and Martinez-Ciriano, {Jose P} and Greet Dijkman and Hoyng, {Carel B} and Sascha Fauser and Suzanne Yzer and Boon, {Camiel JF}",

year = "2018",

doi = "10.2147/OPTH.S174573",

language = "English",

volume = "12",

pages = "2167--2176",

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T1 - Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy

AU - Mohabati, Danial

AU - van Dijk, Elon H C

AU - van Rijssen, Thomas J

AU - de Jong, Eiko K

AU - Breukink, Myrte B

AU - Martinez-Ciriano, Jose P

AU - Dijkman, Greet

AU - Hoyng, Carel B

AU - Fauser, Sascha

AU - Yzer, Suzanne

AU - Boon, Camiel JF

PY - 2018

Y1 - 2018

N2 - Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple "hot spots" of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit.Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.

AB - Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple "hot spots" of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit.Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.

U2 - 10.2147/OPTH.S174573

DO - 10.2147/OPTH.S174573

M3 - Article

C2 - 30498331

SN - 1177-5467

VL - 12

SP - 2167

EP - 2176

JO - Clinical ophthalmology (Auckland, N.Z.)

JF - Clinical ophthalmology (Auckland, N.Z.)

ER -

Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy

Abstract

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