TY - JOUR
T1 - Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy
AU - Thiadens, Alberta A H J
AU - Phan, T My Lan
AU - Zekveld-Vroon, Renate C
AU - Leroy, Bart P
AU - van den Born, L Ingeborgh
AU - Hoyng, Carel B
AU - Klaver, Caroline C W
AU - Roosing, Susanne
AU - Pott, Jan-Willem R
AU - van Schooneveld, Mary J
AU - van Moll-Ramirez, Norka
AU - van Genderen, Maria M
AU - Boon, Camiel J F
AU - den Hollander, Anneke I
AU - Bergen, Arthur A B
AU - De Baere, Elfride
AU - Cremers, Frans P M
AU - Lotery, Andrew J
N1 - Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
PY - 2012/4
Y1 - 2012/4
N2 - OBJECTIVE: To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD).DESIGN: Clinic-based, longitudinal, multicenter study.PARTICIPANTS: Consecutive probands with CD (N = 98), CRD (N = 83), and affected relatives (N = 41 and N = 17, respectively) from various ophthalmogenetic clinics in The Netherlands, Belgium, and the United Kingdom.METHODS: Data on best-corrected Snellen visual acuity, color vision, ophthalmoscopy, fundus photography, Goldmann perimetry, and full-field standard electroretinogram (ERG) from all patients were registered from medical charts over a mean follow-up of 19 years. The ABCA4, CNGB3, KCNV2, PDE6C, and RPGR genes were analyzed by direct sequencing in autosomal recessive (AR) and X-linked (XL), respectively. Genotyping was not undertaken for autosomal-dominant cases.MAIN OUTCOME MEASURES: The 10-year progression of all clinical parameters and cumulative lifetime risk of low vision and legal blindness were assessed.RESULTS: The mean age onset for CD was 16 years (standard deviation, 11), and of CRD 12 years (standard deviation, 11; P = 0.02). The pattern of inheritance was AR in 92% of CD and 90% of CRD. Ten years after diagnosis, 35% of CD and 51% of CRD had a bull's eye maculopathy; 70% of CRD showed absolute peripheral visual field defects and 37% of CD developed rod involvement on ERG. The mean age of legal blindness was 48 (standard error [SE], 3.1) years in CD, and 35 (SE, 1.1; P<0.001) years in CRD. ABCA4 mutations were found in 8 of 90 (9%) of AR-CD, and in 17 of 65 (26%) of AR-CRD. Other mutations were detected in CNGB3 (3/90; 3%), KCNV2 (4/90; 4%), and in PDE6C (1/90; 1%). The RPGR gene was mutated in the 2 XL-CD and in 4 of 5 (80%) of XL-CRD. ABCA4 mutations as well as age of onset <20 years were significantly associated with a faster progression to legal blindness (P<0.001).CONCLUSIONS: Although CD had a slightly more favorable clinical course than CRD, both disorders progressed to legal blindness in the majority of patients. Mutations in the ABCA4 gene and early onset of disease were independent prognostic parameters for visual loss. Our data may serve as an aid in counseling patients with progressive cone disorders.
AB - OBJECTIVE: To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD).DESIGN: Clinic-based, longitudinal, multicenter study.PARTICIPANTS: Consecutive probands with CD (N = 98), CRD (N = 83), and affected relatives (N = 41 and N = 17, respectively) from various ophthalmogenetic clinics in The Netherlands, Belgium, and the United Kingdom.METHODS: Data on best-corrected Snellen visual acuity, color vision, ophthalmoscopy, fundus photography, Goldmann perimetry, and full-field standard electroretinogram (ERG) from all patients were registered from medical charts over a mean follow-up of 19 years. The ABCA4, CNGB3, KCNV2, PDE6C, and RPGR genes were analyzed by direct sequencing in autosomal recessive (AR) and X-linked (XL), respectively. Genotyping was not undertaken for autosomal-dominant cases.MAIN OUTCOME MEASURES: The 10-year progression of all clinical parameters and cumulative lifetime risk of low vision and legal blindness were assessed.RESULTS: The mean age onset for CD was 16 years (standard deviation, 11), and of CRD 12 years (standard deviation, 11; P = 0.02). The pattern of inheritance was AR in 92% of CD and 90% of CRD. Ten years after diagnosis, 35% of CD and 51% of CRD had a bull's eye maculopathy; 70% of CRD showed absolute peripheral visual field defects and 37% of CD developed rod involvement on ERG. The mean age of legal blindness was 48 (standard error [SE], 3.1) years in CD, and 35 (SE, 1.1; P<0.001) years in CRD. ABCA4 mutations were found in 8 of 90 (9%) of AR-CD, and in 17 of 65 (26%) of AR-CRD. Other mutations were detected in CNGB3 (3/90; 3%), KCNV2 (4/90; 4%), and in PDE6C (1/90; 1%). The RPGR gene was mutated in the 2 XL-CD and in 4 of 5 (80%) of XL-CRD. ABCA4 mutations as well as age of onset <20 years were significantly associated with a faster progression to legal blindness (P<0.001).CONCLUSIONS: Although CD had a slightly more favorable clinical course than CRD, both disorders progressed to legal blindness in the majority of patients. Mutations in the ABCA4 gene and early onset of disease were independent prognostic parameters for visual loss. Our data may serve as an aid in counseling patients with progressive cone disorders.
KW - ATP-Binding Cassette Transporters/genetics
KW - Adolescent
KW - Age of Onset
KW - Blindness/physiopathology
KW - Child
KW - Color Vision Defects/physiopathology
KW - Cyclic Nucleotide Phosphodiesterases, Type 6/genetics
KW - Cyclic Nucleotide-Gated Cation Channels/genetics
KW - DNA Mutational Analysis
KW - Electroretinography
KW - Eye Proteins/genetics
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Mutation
KW - Ophthalmoscopy
KW - Polymerase Chain Reaction
KW - Potassium Channels, Voltage-Gated/genetics
KW - Retinitis Pigmentosa/genetics
KW - Vision, Low/physiopathology
KW - Visual Acuity/physiology
KW - Visual Field Tests
U2 - 10.1016/j.ophtha.2011.10.011
DO - 10.1016/j.ophtha.2011.10.011
M3 - Article
C2 - 22264887
SN - 0161-6420
VL - 119
SP - 819
EP - 826
JO - Ophthalmology
JF - Ophthalmology
IS - 4
ER -