Cellular Angiofibroma of the Orbit

Gijsbert J Hötte, Robert M Verdijk, M Gardeniers, Dion Paridaens

Research output: Contribution to journalLetterpeer-review


Cellular angiofibroma is a benign mesenchymal tumor most commonly located in the distal genital tract of both men and women. Although extragenital locations have been reported rarely, this is the first report of cellular angiofibroma of the orbit. A 58-year-old man presented with a mass in the left superomedial orbit since 2 years. Magnetic resonance imaging showed a well-demarcated lesion with a homogeneous intermediate signal intensity on both T1- and T2-weighted images, homogeneous contrast enhancement and high signal intensity on diffusion-weighted images. Complete excision was performed through a medial upper eyelid crease incision. Histopathology showed a vascular CD34-positive and STAT6-negative spindle cell tumor with monoallelic loss of FOXO1, indicating cellular angiofibroma.
Original languageEnglish
Pages (from-to)329-332
Number of pages4
Issue number4
Publication statusPublished - Aug 2021


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