Caruncle tumor as the first sign of metastatic lung carcinoma

Angela Lie; Cornelia Mooy; Willem van den Bosch; Dion Paridaens

doi:10.1016/s0002-9394(02)01571-4

Caruncle tumor as the first sign of metastatic lung carcinoma

Angela Lie, Cornelia Mooy, Willem van den Bosch, Dion Paridaens

Orbita and oculoplastic surgery

Research output: Contribution to journal › Letter › peer-review

Abstract

PURPOSE: Report of a neuroendocrine carcinoma of the caruncle as the first sign of a metastatic lung carcinoma.

DESIGN: Interventional case report.

METHODS: Excision of a rapidly growing caruncular tumor in a 76-year-old woman with a history of breast cancer.

RESULTS: Pathology revealed a large cell neuroendocrine carcinoma, consistent with metastatic lung carcinoma. Computerized tomography of chest, abdomen, and a bone scan disclosed signs of malignancy in the lungs, liver, and bones, originally considered as metastatic breast cancer. However, this diagnosis was excluded on the basis of histopathological findings and clonality analysis. A primary neuroendocrine (Merkel cell) carcinoma was ruled out on morphologic and immunohistochemical grounds.

CONCLUSION: We present a unique case of a metastatic large cell neuroendocrine carcinoma of the caruncle.

Original language	English
Pages (from-to)	438-9
Number of pages	2
Journal	American Journal of Ophthalmology
Volume	134
Issue number	3
DOIs	https://doi.org/10.1016/s0002-9394(02)01571-4
Publication status	Published - Sept 2002

Keywords

Aged
Biomarkers, Tumor/analysis
Carcinoma, Large Cell/chemistry
Carcinoma, Neuroendocrine/chemistry
Conjunctival Neoplasms/chemistry
Female
Humans
Immunoenzyme Techniques
Lung Neoplasms/chemistry
Synaptophysin/analysis

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10.1016/s0002-9394(02)01571-4

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title = "Caruncle tumor as the first sign of metastatic lung carcinoma",

abstract = "PURPOSE: Report of a neuroendocrine carcinoma of the caruncle as the first sign of a metastatic lung carcinoma.DESIGN: Interventional case report.METHODS: Excision of a rapidly growing caruncular tumor in a 76-year-old woman with a history of breast cancer.RESULTS: Pathology revealed a large cell neuroendocrine carcinoma, consistent with metastatic lung carcinoma. Computerized tomography of chest, abdomen, and a bone scan disclosed signs of malignancy in the lungs, liver, and bones, originally considered as metastatic breast cancer. However, this diagnosis was excluded on the basis of histopathological findings and clonality analysis. A primary neuroendocrine (Merkel cell) carcinoma was ruled out on morphologic and immunohistochemical grounds.CONCLUSION: We present a unique case of a metastatic large cell neuroendocrine carcinoma of the caruncle.",

keywords = "Aged, Biomarkers, Tumor/analysis, Carcinoma, Large Cell/chemistry, Carcinoma, Neuroendocrine/chemistry, Conjunctival Neoplasms/chemistry, Female, Humans, Immunoenzyme Techniques, Lung Neoplasms/chemistry, Synaptophysin/analysis",

author = "Angela Lie and Cornelia Mooy and {van den Bosch}, Willem and Dion Paridaens",

year = "2002",

month = sep,

doi = "10.1016/s0002-9394(02)01571-4",

language = "English",

volume = "134",

pages = "438--9",

number = "3",

}

TY - JOUR

T1 - Caruncle tumor as the first sign of metastatic lung carcinoma

AU - Lie, Angela

AU - Mooy, Cornelia

AU - van den Bosch, Willem

AU - Paridaens, Dion

PY - 2002/9

Y1 - 2002/9

N2 - PURPOSE: Report of a neuroendocrine carcinoma of the caruncle as the first sign of a metastatic lung carcinoma.DESIGN: Interventional case report.METHODS: Excision of a rapidly growing caruncular tumor in a 76-year-old woman with a history of breast cancer.RESULTS: Pathology revealed a large cell neuroendocrine carcinoma, consistent with metastatic lung carcinoma. Computerized tomography of chest, abdomen, and a bone scan disclosed signs of malignancy in the lungs, liver, and bones, originally considered as metastatic breast cancer. However, this diagnosis was excluded on the basis of histopathological findings and clonality analysis. A primary neuroendocrine (Merkel cell) carcinoma was ruled out on morphologic and immunohistochemical grounds.CONCLUSION: We present a unique case of a metastatic large cell neuroendocrine carcinoma of the caruncle.

AB - PURPOSE: Report of a neuroendocrine carcinoma of the caruncle as the first sign of a metastatic lung carcinoma.DESIGN: Interventional case report.METHODS: Excision of a rapidly growing caruncular tumor in a 76-year-old woman with a history of breast cancer.RESULTS: Pathology revealed a large cell neuroendocrine carcinoma, consistent with metastatic lung carcinoma. Computerized tomography of chest, abdomen, and a bone scan disclosed signs of malignancy in the lungs, liver, and bones, originally considered as metastatic breast cancer. However, this diagnosis was excluded on the basis of histopathological findings and clonality analysis. A primary neuroendocrine (Merkel cell) carcinoma was ruled out on morphologic and immunohistochemical grounds.CONCLUSION: We present a unique case of a metastatic large cell neuroendocrine carcinoma of the caruncle.

KW - Aged

KW - Biomarkers, Tumor/analysis

KW - Carcinoma, Large Cell/chemistry

KW - Carcinoma, Neuroendocrine/chemistry

KW - Conjunctival Neoplasms/chemistry

KW - Female

KW - Humans

KW - Immunoenzyme Techniques

KW - Lung Neoplasms/chemistry

KW - Synaptophysin/analysis

U2 - 10.1016/s0002-9394(02)01571-4

DO - 10.1016/s0002-9394(02)01571-4

M3 - Letter

C2 - 12208258

SN - 0002-9394

VL - 134

SP - 438

EP - 439

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 3

ER -

Caruncle tumor as the first sign of metastatic lung carcinoma

Abstract

Keywords

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