Abstract
Two patients in whom ocular Lyme disease was suspected and who had antibodies to Borrelia burgdorferi developed birdshot chorioretinopathy and carried the HLA-A29 antigen. In a series of 11 patients with birdshot chorioretinopathy who carried the HLA-A29 antigen, three patients had antibodies against B. burgdorferi as determined by either immunofluorescence assay, enzyme-linked immunosorbent assay, Western blot analysis, or a combination of these tests. Further studies will be necessary to evaluate whether this is a false-positive reaction or whether B. burgdorferi has a causative role in the pathogenesis of birdshot chorioretinopathy.
Original language | English |
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Pages (from-to) | 149-53 |
Number of pages | 5 |
Journal | American Journal of Ophthalmology |
Volume | 115 |
Issue number | 2 |
DOIs | |
Publication status | Published - 15 Feb 1993 |
Keywords
- Blotting, Western
- Borrelia burgdorferi Group/isolation & purification
- Chorioretinitis/diagnostic imaging
- Enzyme-Linked Immunosorbent Assay
- False Positive Reactions
- Fluorescein Angiography
- Fluorescent Antibody Technique
- HLA-A Antigens/analysis
- Humans
- Lyme Disease/complications
- Radiography
- Visual Acuity