Biopsy-proven recurrence of unilateral IgG4-related orbital inflammation after 20 years

Pegah Heidari, Robert M Verdijk, W A van den Bosch, Dion Paridaens

Research output: Contribution to journalLetterpeer-review


A 38-year-old female patient presented with a painful swelling in the lateral part of the upper eyelid, a diffuse scleritis and slight hypoglobus of the right eye. An orbital biopsy showed a fibrotic idiopathic orbital inflammation (IOI) with, on immunohistochemical staining, an increased number of IgG4-positive plasma cells scored as >200 per high-power field, with IgG4/IgG ratio >0.50, indicating orbital IgG4 related autoimmune disease. On treatment with oral prednisone and azathioprine the symptoms resolved within 6 months. Twenty years prior, the patient had been diagnosed with an IOI of at the same side, for which at that time a biopsy had been taken similarly. Reclassification of the previous biopsy specimen with immunohistological staining also showed evidence of orbital IgG4 related disease. To our knowledge this is the first report of a biopsy-proven unilateral IgG4-related orbitopathy that recurred after 20 years.

Original languageEnglish
Pages (from-to)388-91
Number of pages4
JournalOrbit (Amsterdam, Netherlands)
Issue number5
Publication statusPublished - Oct 2014


  • Administration, Oral
  • Adult
  • Azathioprine/therapeutic use
  • Biopsy
  • Drug Therapy, Combination
  • Female
  • Glucocorticoids/therapeutic use
  • Humans
  • Hypergammaglobulinemia/diagnosis
  • Immunoglobulin G/blood
  • Immunosuppressive Agents/therapeutic use
  • Orbital Pseudotumor/diagnosis
  • Prednisone/therapeutic use
  • Recurrence
  • Time Factors
  • Tomography, X-Ray Computed


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