Attenuation coefficient estimation in Fourier-domain OCT of multi-layered phantoms

Babak Ghafaryasl, Koenraad Arndt Vermeer, Jeroen Kalkman, Tom Callewaert, Johannes F de Boer, Lucas J van Vliet

Research output: Contribution to journalArticleResearchpeer-review


Optical properties, such as the attenuation coefficients of multi-layer tissue samples, could be used as a biomarker for diagnosis and disease progression in clinical practice. In this paper, we present a method to estimate the attenuation coefficients in a multi-layer sample by fitting a single scattering model for the OCT signal to the recorded OCT signal. In addition, we employ numerical simulations to obtain the theoretically achievable precision and accuracy of the estimated parameters under various experimental conditions. Finally, the method is applied to two sets of measurements obtained from a multi-layer phantom by two experimental OCT systems: one with a large and one with a small Rayleigh length. Numerical and experimental results show an accurate estimation of the attenuation coefficients when using multiple B-scans.
Original languageEnglish
Pages (from-to)2744-2758
Number of pages15
JournalBiomedical Optics Express
Issue number5
Publication statusPublished - May 2021


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