Association of birdshot retinochoroidopathy and HLA-A29 antigen

G S Baarsma, H A Priem, A Kijlstra

Research output: Contribution to journalArticleResearchpeer-review


In 1980 Ryan and Maumenee described a new clinical entity characterized by hypopigmented spots in a typical patterned distribution in association with vitritis and retinal vasculopathy leading to cystoid macular oedema and papilloedema. In a recent study of a large group of European patients (n = 102) with birdshot retinochoroidopathy, the importance of the different clinical manifestations and their diagnostic value were assessed. Data on HLA-A29 typing were obtained in 49 patients with birdshot retinochoroidopathy. We could confirm the high association between HLA-A29 and this disease, as found by Nussenblatt in 1982. In 47 of these patients (95.5%) the HLA-A29 antigen was present. This association is presently the highest HLA class I disease association reported with a relative risk of 224.35.

Original languageEnglish
Pages (from-to)63-8
Number of pages6
JournalCurrent Eye Research
Volume9 Suppl
Publication statusPublished - 1990


  • Choroid Diseases/immunology
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • HLA-A Antigens/blood
  • Histocompatibility Testing
  • Humans
  • Male
  • Phenotype
  • Retinal Diseases/immunology
  • Risk Factors
  • Uveitis/immunology


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