Abstract
We analyzed the local antibody production in vitreous humor samples collected during vitrectomy in patients with severe vision-threatening uveitis. In 24 patients, paired serum and undiluted vitreous humor samples were collected and tested for antibodies against Toxoplasma gondii, herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, and Toxocara canis. Total IgG and the Goldmann-Witmer coefficient were determined. The initial diagnosis of ocular toxoplasmosis could be confirmed in six of the seven patients. The seventh patient showed a local antibody production against herpes simplex virus. One of the three patients with chronic panuveitis at initial diagnosis showed a local antibody production against T. gondii. These last two findings resulted in a change in medical treatment. Analysis of local antibody production in vitreous humor samples is a valuable diagnostic tool.
| Original language | English |
|---|---|
| Pages (from-to) | 147-50 |
| Number of pages | 4 |
| Journal | American Journal of Ophthalmology |
| Volume | 112 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 15 Aug 1991 |
Keywords
- Animals
- Antibodies/analysis
- Antibodies, Protozoan/analysis
- Antibodies, Viral/analysis
- Antibody Formation
- Humans
- Simplexvirus/immunology
- Toxoplasma/immunology
- Uveitis/immunology
- Vitrectomy
- Vitreous Body/immunology