An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses

Marc A Veckeneer; Simone de Voogd; Eric W Lindstedt; Dirk-Henning Menz; Jan C van Meurs

doi:10.1007/s00417-008-0768-9

An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses

Marc A Veckeneer, Simone de Voogd, Eric W Lindstedt, Dirk-Henning Menz, Jan C van Meurs

Vitreoretinal surgery

Research output: Contribution to journal › Article › Research › peer-review

Abstract

PURPOSE: To report and study the phenomenon of abnormal silicone oil adherent to the retina at the time of removal in a number of patients.

MATERIALS AND METHODS: Chart review was performed to identify possible patient or procedural factors that could predispose to sticky silicone oil formation. Gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy analyses were performed on sticky silicone oil samples, on perfluorocarbon liquid and on silicone oil samples straight from the vial.

RESULTS: Sticky silicone oil remnants were seen on the retina in 28 out of 234 silicone oil removal procedures between January 2001 and November 2002. Forceful removal was complicated in two patients by a choroidal hemorrhage and in one patient by a retinal tear. The use of perfluoro-octane (PFO; C(8)F(18)) rather than perfluorodecalin (C(10)F(18)) was related to the phenomenon (P < 0.001). Gas chromatography-mass spectroscopy analysis revealed a significant presence of PFO in samples of sticky silicone oil, and traces of partially fluorinated carbon liquid were found in the sticky oil as well as in the PFO samples.

CONCLUSIONS: The use of PFO may have been a predisposing factor for the occurrence of sticky silicone oil. While the presence of silicone oil remnants on the retina did not cause lasting side effect, forceful attempts at removal can lead to complications.

Original language	English
Pages (from-to)	917-22
Number of pages	6
Journal	Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Volume	246
Issue number	6
DOIs	https://doi.org/10.1007/s00417-008-0768-9
Publication status	Published - Jun 2008

Keywords

Adhesiveness
Drainage/methods
Drug Interactions
Female
Fluorocarbons/chemistry
Gas Chromatography-Mass Spectrometry
Humans
Intraoperative Complications
Magnetic Resonance Spectroscopy
Male
Middle Aged
Retina/metabolism
Retinal Detachment/surgery
Retrospective Studies
Silicone Oils/chemistry
Vitrectomy

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10.1007/s00417-008-0768-9

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Veckeneer, M. A., de Voogd, S., Lindstedt, E. W., Menz, D.-H., & van Meurs, J. C. (2008). An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 246(6), 917-22. https://doi.org/10.1007/s00417-008-0768-9

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title = "An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses",

abstract = "PURPOSE: To report and study the phenomenon of abnormal silicone oil adherent to the retina at the time of removal in a number of patients.MATERIALS AND METHODS: Chart review was performed to identify possible patient or procedural factors that could predispose to sticky silicone oil formation. Gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy analyses were performed on sticky silicone oil samples, on perfluorocarbon liquid and on silicone oil samples straight from the vial.RESULTS: Sticky silicone oil remnants were seen on the retina in 28 out of 234 silicone oil removal procedures between January 2001 and November 2002. Forceful removal was complicated in two patients by a choroidal hemorrhage and in one patient by a retinal tear. The use of perfluoro-octane (PFO; C(8)F(18)) rather than perfluorodecalin (C(10)F(18)) was related to the phenomenon (P < 0.001). Gas chromatography-mass spectroscopy analysis revealed a significant presence of PFO in samples of sticky silicone oil, and traces of partially fluorinated carbon liquid were found in the sticky oil as well as in the PFO samples.CONCLUSIONS: The use of PFO may have been a predisposing factor for the occurrence of sticky silicone oil. While the presence of silicone oil remnants on the retina did not cause lasting side effect, forceful attempts at removal can lead to complications.",

keywords = "Adhesiveness, Drainage/methods, Drug Interactions, Female, Fluorocarbons/chemistry, Gas Chromatography-Mass Spectrometry, Humans, Intraoperative Complications, Magnetic Resonance Spectroscopy, Male, Middle Aged, Retina/metabolism, Retinal Detachment/surgery, Retrospective Studies, Silicone Oils/chemistry, Vitrectomy",

author = "Veckeneer, {Marc A} and {de Voogd}, Simone and Lindstedt, {Eric W} and Dirk-Henning Menz and {van Meurs}, {Jan C}",

year = "2008",

month = jun,

doi = "10.1007/s00417-008-0768-9",

language = "English",

volume = "246",

pages = "917--22",

number = "6",

}

Veckeneer, MA, de Voogd, S, Lindstedt, EW, Menz, D-H & van Meurs, JC 2008, 'An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses', Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, vol. 246, no. 6, pp. 917-22. https://doi.org/10.1007/s00417-008-0768-9

An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses. / Veckeneer, Marc A; de Voogd, Simone; Lindstedt, Eric W et al.
In: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Vol. 246, No. 6, 06.2008, p. 917-22.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses

AU - Veckeneer, Marc A

AU - de Voogd, Simone

AU - Lindstedt, Eric W

AU - Menz, Dirk-Henning

AU - van Meurs, Jan C

PY - 2008/6

Y1 - 2008/6

N2 - PURPOSE: To report and study the phenomenon of abnormal silicone oil adherent to the retina at the time of removal in a number of patients.MATERIALS AND METHODS: Chart review was performed to identify possible patient or procedural factors that could predispose to sticky silicone oil formation. Gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy analyses were performed on sticky silicone oil samples, on perfluorocarbon liquid and on silicone oil samples straight from the vial.RESULTS: Sticky silicone oil remnants were seen on the retina in 28 out of 234 silicone oil removal procedures between January 2001 and November 2002. Forceful removal was complicated in two patients by a choroidal hemorrhage and in one patient by a retinal tear. The use of perfluoro-octane (PFO; C(8)F(18)) rather than perfluorodecalin (C(10)F(18)) was related to the phenomenon (P < 0.001). Gas chromatography-mass spectroscopy analysis revealed a significant presence of PFO in samples of sticky silicone oil, and traces of partially fluorinated carbon liquid were found in the sticky oil as well as in the PFO samples.CONCLUSIONS: The use of PFO may have been a predisposing factor for the occurrence of sticky silicone oil. While the presence of silicone oil remnants on the retina did not cause lasting side effect, forceful attempts at removal can lead to complications.

AB - PURPOSE: To report and study the phenomenon of abnormal silicone oil adherent to the retina at the time of removal in a number of patients.MATERIALS AND METHODS: Chart review was performed to identify possible patient or procedural factors that could predispose to sticky silicone oil formation. Gas chromatography-mass spectroscopy and nuclear magnetic resonance spectroscopy analyses were performed on sticky silicone oil samples, on perfluorocarbon liquid and on silicone oil samples straight from the vial.RESULTS: Sticky silicone oil remnants were seen on the retina in 28 out of 234 silicone oil removal procedures between January 2001 and November 2002. Forceful removal was complicated in two patients by a choroidal hemorrhage and in one patient by a retinal tear. The use of perfluoro-octane (PFO; C(8)F(18)) rather than perfluorodecalin (C(10)F(18)) was related to the phenomenon (P < 0.001). Gas chromatography-mass spectroscopy analysis revealed a significant presence of PFO in samples of sticky silicone oil, and traces of partially fluorinated carbon liquid were found in the sticky oil as well as in the PFO samples.CONCLUSIONS: The use of PFO may have been a predisposing factor for the occurrence of sticky silicone oil. While the presence of silicone oil remnants on the retina did not cause lasting side effect, forceful attempts at removal can lead to complications.

KW - Adhesiveness

KW - Drainage/methods

KW - Drug Interactions

KW - Female

KW - Fluorocarbons/chemistry

KW - Gas Chromatography-Mass Spectrometry

KW - Humans

KW - Intraoperative Complications

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Middle Aged

KW - Retina/metabolism

KW - Retinal Detachment/surgery

KW - Retrospective Studies

KW - Silicone Oils/chemistry

KW - Vitrectomy

U2 - 10.1007/s00417-008-0768-9

DO - 10.1007/s00417-008-0768-9

M3 - Article

C2 - 18299876

SN - 0721-832X

VL - 246

SP - 917

EP - 922

JO - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

IS - 6

ER -

An epidemic of sticky silicone oil at the Rotterdam Eye Hospital. Patient review and chemical analyses

Abstract

Keywords

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