Adhesion molecules in iris biopsy specimens from patients with uveitis

Ellen C La Heij, R W Kuijpers, S G Baarsma, A Kijlstra, M van der Weiden, C M Mooy

Research output: Contribution to journalArticleResearchpeer-review


BACKGROUND/AIMS: Earlier studies on intraocular tissue have demonstrated that T lymphocytes play a major role in the pathogenesis of uveitis. Adhesion molecules are immunoregulatory molecules for the interaction between T lymphocytes and vascular endothelium and they play an important role in the recruitment of specific T lymphocytes from the circulation into inflamed tissue. In uveitis an increased expression of some of these adhesion molecules may be expected.

METHODS: The presence of adhesion molecules was investigated in iris biopsy specimens from 11 patients with uveitis and eight controls (patients with primary open angle glaucoma) immunohistochemically with a panel of monoclonal antibodies: LECAM (CD 62L), ICAM-1 (CD 54), LFA-1 (CD 11a/18), VCAM-1 (CD 106), VLA-4 (CD 49d), and HECA-452, a marker for high endothelial venules.

RESULTS: Positive staining for ICAM-1, LFA-1 and VCAM-1 was found in the iris in a significantly higher number of uveitis patients than in controls. The remaining adhesion molecules were also found in a higher number of uveitis patients than in controls, but this difference did not reach statistical significance.

CONCLUSION: An increased expression of adhesion molecules was found in the iris of patients with uveitis, indicating an immunoregulatory function for adhesion molecules in the pathogenesis of uveitis.

Original languageEnglish
Pages (from-to)432-7
Number of pages6
JournalBritish Journal of Ophthalmology
Issue number4
Publication statusPublished - Apr 1998


  • Adult
  • Aged
  • Aged, 80 and over
  • Cell Adhesion Molecules/analysis
  • Female
  • Glaucoma, Open-Angle/metabolism
  • Humans
  • Immunohistochemistry
  • Intercellular Adhesion Molecule-1/analysis
  • Iris/chemistry
  • Lymphocyte Function-Associated Antigen-1/analysis
  • Male
  • Middle Aged
  • Uveitis/immunology
  • Vascular Cell Adhesion Molecule-1/analysis


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